InnateDB Protein
|
IDBP-156519.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Slc1a1
|
Protein Name
|
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
|
Synonyms
|
D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000025875
|
InnateDB Gene
|
IDBG-156517 (Slc1a1)
|
Protein Structure
|
|
Function |
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.
|
Subcellular Localization |
Membrane; Multi-pass membrane protein.
|
Disease Associations |
|
Tissue Specificity |
Expressed in brain, lung, kidney and skeletal muscle.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:105083
|
InterPro |
IPR001991
Sodium:dicarboxylate symporter
|
PFAM |
PF00375
|
PRINTS |
PR00173
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P51906
|
PhosphoSite |
PhosphoSite-P51906
|
TrEMBL |
Q9QWI2
|
UniProt Splice Variant |
|
Entrez Gene |
20510
|
UniGene |
Mm.400146
|
RefSeq |
NP_033225
|
MGI ID |
|
MGI Symbol |
Slc1a1
|
OMIM |
|
CCDS |
CCDS29727
|
HPRD |
|
IMGT |
|
EMBL |
AF322393
BC065099
CH466534
D43797
U73521
U75214
U75216
U75217
|
GenPept |
AAB71739
AAB71741
AAB71742
AAB80694
AAH65099
AAL37243
AAL37244
BAA07855
EDL41660
|
|
|