Version 5.4
Mus musculus Protein: Dedd2
Summary
InnateDB Protein IDBP-156543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dedd2
Protein Name death effector domain-containing DNA binding protein 2
Synonyms 2410050E11Rik; FLAME-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000049763
InnateDB Gene IDBG-156541 (Dedd2)
Protein Structure
UniProt Annotation
Function May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli. {ECO:0000250}.
Disease Associations
Tissue Specificity Expression is high in liver, heart, kidney, and testis but low in brain, spleen, lung, and skeleton muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0030262 apoptotic nuclear changes
GO:0042981 regulation of apoptotic process
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:1914629
InterPro IPR001875 Death effector domain
IPR011029 Death-like domain
PFAM PF01335
PRINTS
PIRSF
SMART SM00031
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8QZV0
PhosphoSite PhosphoSite-Q8QZV0
TrEMBL
UniProt Splice Variant
Entrez Gene 67379
UniGene
RefSeq NP_997560
MGI ID
MGI Symbol Dedd2
OMIM
CCDS CCDS20973
HPRD
IMGT
EMBL AF457576 AF543541 BC092250
GenPept AAH92250 AAM10836 AAN33179

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca