InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mc2r

Summary

InnateDB Protein

IDBP-156597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mc2r

Protein Name

melanocortin 2 receptor

Synonyms

ACTH-R; ACTHR; MC2-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058691

InnateDB Gene

IDBG-156595 (Mc2r)

Protein Structure

UniProt Annotation

Function

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004978	corticotropin receptor activity
GO:0005515	protein binding

Biological Process

GO:0001890	placenta development
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96928

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001168 Adrenocorticotrophin (ACTH) receptor
IPR001671 Melanocortin/ACTH receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00520
PR00534

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64326