Version 5.4
Mus musculus Protein: Dolpp1
Summary
InnateDB Protein IDBP-156603.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dolpp1
Protein Name dolichyl pyrophosphate phosphatase 1
Synonyms 0610011H20Rik; AB030189; LSFR2;
Species Mus musculus
Ensembl Protein ENSMUSP00000028209
InnateDB Gene IDBG-156601 (Dolpp1)
Protein Structure
UniProt Annotation
Function Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. {ECO:0000269PubMed:12198133}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:12198133}; Multi-pass membrane protein {ECO:0000269PubMed:12198133}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain, kidney, lung and intestine. {ECO:0000269PubMed:12198133}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0047874 dolichyldiphosphatase activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1914093
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMF7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 57170
UniGene Mm.421192
RefSeq NP_065062
MGI ID
MGI Symbol Dolpp1
OMIM
CCDS CCDS15881
HPRD
IMGT
EMBL AB030189 AK002544 AK010797 AK044141 AK053923 BC026544
GenPept AAH26544 BAA92753 BAB27187 BAC24998 BAC31797 BAC35595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca