InnateDB Protein
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IDBP-156616.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dok7
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Protein Name
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docking protein 7
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059538
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InnateDB Gene
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IDBG-156612 (Dok7)
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Protein Structure
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Function |
Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269PubMed:16794080, ECO:0000269PubMed:20603078}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:16794080}; Peripheral membrane protein {ECO:0000269PubMed:16794080}. Cell junction, synapse {ECO:0000269PubMed:16794080}. Note=Accumulates at neuromuscular junctions.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0001934
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positive regulation of protein phosphorylation
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GO:0007528
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neuromuscular junction development
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GO:0043113
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receptor clustering
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GO:0061098
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positive regulation of protein tyrosine kinase activity
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Cellular Component |
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PDB ID |
MGI:3584043
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InterPro |
IPR002404
Insulin receptor substrate-1, PTB
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PFAM |
PF02174
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PRINTS |
PR00628
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PIRSF |
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SMART |
SM00310
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TIGRFAMs |
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Modification |
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SwissProt |
Q18PE0
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PhosphoSite |
PhosphoSite-Q18PE0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
231134
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UniGene |
Mm.205483
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RefSeq |
NP_766296
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MGI ID |
3ML4
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MGI Symbol |
Dok7
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OMIM |
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CCDS |
CCDS19224
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HPRD |
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IMGT |
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EMBL |
AB220919
AK044445
AK170454
BC089590
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GenPept |
AAH89590
BAC31923
BAE41809
BAE96740
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