Version 5.4
Mus musculus Protein: Ip6k3
Summary
InnateDB Protein IDBP-156622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ip6k3
Protein Name inositol hexaphosphate kinase 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000025046
InnateDB Gene IDBG-156620 (Ip6k3)
Protein Structure
UniProt Annotation
Function Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in cerebellum, brain cortex, kidney, thymus and lung. Detected at lower levels in hippocampus, testis, heart and olfactory bulb. {ECO:0000269PubMed:11502751}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000831 inositol hexakisphosphate 6-kinase activity
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3045325
InterPro IPR005522 Inositol polyphosphate kinase
PFAM PF03770
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BWD2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 271424
UniGene Mm.209679
RefSeq NP_766615
MGI ID
MGI Symbol Ip6k3
OMIM
CCDS CCDS28562
HPRD
IMGT
EMBL AK052857
GenPept BAC35176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca