InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxh1

Summary

InnateDB Protein

IDBP-156646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxh1

Protein Name

forkhead box H1

Synonyms

fast-1; fast-2; Fast1; Fast2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036591

InnateDB Gene

IDBG-156644 (Foxh1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269PubMed:10349617, ECO:0000269PubMed:9702197, ECO:0000269PubMed:9858566, ECO:0000269Ref.4}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046332	SMAD binding
GO:0050681	androgen receptor binding
GO:0070410	co-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001947	heart looping
GO:0003139	secondary heart field specification
GO:0003151	outflow tract morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007368	determination of left/right symmetry
GO:0009952	anterior/posterior pattern specification
GO:0010159	specification of organ position
GO:0021508	floor plate formation
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0035054	embryonic heart tube anterior/posterior pattern specification
GO:0035909	aorta morphogenesis
GO:0042074	cell migration involved in gastrulation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048318	axial mesoderm development
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:2000824	negative regulation of androgen receptor activity