InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Erf

Summary

InnateDB Protein

IDBP-156705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erf

Protein Name

Ets2 repressor factor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041912

InnateDB Gene

IDBG-156703 (Erf)

Protein Structure

UniProt Annotation

Function

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation (By similarity). Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation. {ECO:0000250, ECO:0000269PubMed:17502352}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed along the osteogenic margins of the developing calvarial bones, in a similar distribution to that observed for the master osteogenic regulator RUNX2. {ECO:0000269PubMed:23354439}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0010668	ectodermal cell differentiation
GO:0060707	trophoblast giant cell differentiation
GO:0060710	chorio-allantoic fusion