InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim32

Summary

InnateDB Protein

IDBP-156708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim32

Protein Name

tripartite motif-containing 32

Synonyms

1810045E12Rik; 3f3; BBS11; Zfp117;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000062277

InnateDB Gene

IDBG-156706 (Trim32)

Protein Structure

UniProt Annotation

Function

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha. {ECO:0000250, ECO:0000269PubMed:14578165, ECO:0000269PubMed:16816390}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14578165, ECO:0000269PubMed:16816390}. Note=Localized in cytoplasmic bodies, usually concentrated around the nucleus.

Disease Associations

Tissue Specificity

Ubiquitous. High expression in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017022	myosin binding
GO:0031369	translation initiation factor binding
GO:0043130	ubiquitin binding
GO:0043621	protein self-association
GO:0046872	metal ion binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0009411	response to UV
GO:0016567	protein ubiquitination
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0032897	negative regulation of viral transcription
GO:0034612	response to tumor necrosis factor
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045787	positive regulation of cell cycle
GO:0045862	positive regulation of proteolysis
GO:0048147	negative regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1902173	negative regulation of keratinocyte apoptotic process
GO:1902187	negative regulation of viral release from host cell
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000147	positive regulation of cell motility

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005863	striated muscle myosin thick filament

Protein Structure and Domains

PDB ID

MGI:1917057

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001841 Zinc finger, RING-type
IPR013017 NHL repeat, subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF01436
PF13639
PF14634
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CH72