InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRPF1

Summary

InnateDB Protein

IDBP-15679.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRPF1

Protein Name

bromodomain and PHD finger containing, 1

Synonyms

BR140;

Species

Homo sapiens

Ensembl Protein

ENSP00000373340

InnateDB Gene

IDBG-15675 (BRPF1)

Protein Structure

UniProt Annotation

Function

Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2. {ECO:0000269PubMed:16387653, ECO:0000269PubMed:18794358}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18794358}. Cytoplasm {ECO:0000269PubMed:18794358}. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6.

Disease Associations

Tissue Specificity

High levels in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0043966	histone H3 acetylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0070776	MOZ/MORF histone acetyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR001487 Bromodomain
IPR001965 Zinc finger, PHD-type
IPR007087 Zinc finger, C2H2
IPR011011 Zinc finger, FYVE/PHD-type
IPR019542 Enhancer of polycomb-like, N-terminal
IPR019787 Zinc finger, PHD-finger

PFAM

PF00855
PF00439
PF00096
PF10513
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00293
SM00297
SM00249

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt