InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmx1

Summary

InnateDB Protein

IDBP-156797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmx1

Protein Name

H6 homeobox 1

Synonyms

Nkx5-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084958

InnateDB Gene

IDBG-156795 (Hmx1)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. {ECO:0000269PubMed:9628823}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in neural crest-derived tissues, including, nerve ganglia and cranial mesenchyme. {ECO:0000269PubMed:9628823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0045892	negative regulation of transcription, DNA-templated