InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcbd2

Summary

InnateDB Protein

IDBP-156811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcbd2

Protein Name

pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2

Synonyms

2700061N24Rik; Dcoh2; Dcohm;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021958

InnateDB Gene

IDBG-156809 (Pcbd2)

Protein Structure

UniProt Annotation

Function

Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). {ECO:0000250}.Regulates the dimerization of homeodomain protein HNF-1- alpha and enhances its transcriptional activity. {ECO:0000269PubMed:15182178}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004505	phenylalanine 4-monooxygenase activity
GO:0005515	protein binding
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity

Biological Process

GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051289	protein homotetramerization
GO:0051291	protein heterooligomerization
GO:0055114	oxidation-reduction process