InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ntmt1

Summary

InnateDB Protein

IDBP-156881.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ntmt1

Protein Name

methyltransferase like 11A

Synonyms

2610205E22Rik; AL033331; AL033332; Mettl11a; NTM1A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035303

InnateDB Gene

IDBG-156879 (Ntmt1)

Protein Structure

UniProt Annotation

Function

Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. {ECO:0000250, ECO:0000269PubMed:20668449}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008276	protein methyltransferase activity

Biological Process

GO:0007051	spindle organization
GO:0007059	chromosome segregation
GO:0008152	metabolic process
GO:0018012	N-terminal peptidyl-alanine trimethylation
GO:0018016	N-terminal peptidyl-proline dimethylation
GO:0035572	N-terminal peptidyl-serine dimethylation
GO:0035573	N-terminal peptidyl-serine trimethylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1913867

InterPro

IPR001077 O-methyltransferase, family 2
IPR004033 UbiE/COQ5 methyltransferase
IPR008576 Protein of unknown function DUF858, methyltransferase-like
IPR013216 Methyltransferase type 11
IPR013217 Methyltransferase type 12
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00891
PF01209
PF05891
PF08241
PF08242

PRINTS

PIRSF

PIRSF016958

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R2U4