InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcd4

Summary

InnateDB Protein

IDBP-156899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcd4

Protein Name

ATP-binding cassette, sub-family D (ALD), member 4

Synonyms

P69r; P70R; Pxmp1l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021666

InnateDB Gene

IDBG-156897 (Abcd4)

Protein Structure

UniProt Annotation

Function

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0009235	cobalamin metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005777	peroxisome
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1349217

InterPro

IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR010509 Peroxisomal fatty acyl CoA transporter, transmembrane domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00005
PF06472

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O89016