InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt3

Summary

InnateDB Protein

IDBP-156939.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt3

Protein Name

nudix (nucleotide diphosphate linked moiety X)-type motif 3

Synonyms

1110011B09Rik; AA960325; Dipp; Dipp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025050

InnateDB Gene

IDBG-156935 (Nudt3)

Protein Structure

UniProt Annotation

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphophate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). Acts as a negative regulator of the ERK1/2 pathway. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Present in heart, lung, liver and spleen (at protein level). Widely expressed. {ECO:0000269PubMed:15212765}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity
GO:0016787	hydrolase activity
GO:0052840	inositol diphosphate tetrakisphosphate diphosphatase activity
GO:0052843	inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity
GO:0052844	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
GO:0052845	inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
GO:0052846	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
GO:0052847	inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
GO:0052848	inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity