InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Recql4

Summary

InnateDB Protein

IDBP-156945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Recql4

Protein Name

RecQ protein-like 4

Synonyms

RecQ4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044363

InnateDB Gene

IDBG-156943 (Recql4)

Protein Structure

UniProt Annotation

Function

DNA-dependent ATPase (By similarity). May play a role in development of the palate and the limbs. May modulate chromosome segregation. {ECO:0000250, ECO:0000269PubMed:12915449, ECO:0000269PubMed:15703196}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001501	skeletal system development
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006310	DNA recombination
GO:0008284	positive regulation of cell proliferation
GO:0043473	pigmentation
GO:0045875	negative regulation of sister chromatid cohesion
GO:0048705	skeletal system morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1931028

InterPro

IPR001650 Helicase, C-terminal
IPR001878 Zinc finger, CCHC-type
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR021110 DNA replication/checkpoint protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00098
PF00270
PF11719

PRINTS

PIRSF

SMART

SM00490
SM00343
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q75NR7