InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vps11

Summary

InnateDB Protein

IDBP-156967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps11

Protein Name

vacuolar protein sorting 11 (yeast)

Synonyms

1200011A11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034644

InnateDB Gene

IDBG-156965 (Vps11)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0008150	biological_process
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005884	actin filament
GO:0030139	endocytic vesicle
GO:0031902	late endosome membrane

Protein Structure and Domains

PDB ID

MGI:1918982

InterPro

IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001841 Zinc finger, RING-type
IPR016024 Armadillo-type fold
IPR016528 Vacuolar protein sorting-associated protein 11
IPR017986 WD40-repeat-containing domain
IPR024763 Vacuolar protein sorting protein 11, C-terminal

PFAM

PF00637
PF13639
PF14634
PF12451

PRINTS

PIRSF

PIRSF007860

SMART

SM00299
SM00184

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt