InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jak2

Summary

InnateDB Protein

IDBP-156981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jak2

Protein Name

Janus kinase 2

Synonyms

Fd17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025705

InnateDB Gene

IDBG-156977 (Jak2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	93 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005131	growth hormone receptor binding
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0020037	heme binding
GO:0031702	type 1 angiotensin receptor binding
GO:0033130	acetylcholine receptor binding
GO:0035401	histone kinase activity (H3-Y41 specific)
GO:0042169	SH2 domain binding
GO:0042393	histone binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043560	insulin receptor substrate binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007259	JAK-STAT cascade
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007262	STAT protein import into nucleus
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009755	hormone-mediated signaling pathway
GO:0010811	positive regulation of cell-substrate adhesion
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0022408	negative regulation of cell-cell adhesion
GO:0030099	myeloid cell differentiation
GO:0030154	cell differentiation
GO:0030335	positive regulation of cell migration
GO:0031103	axon regeneration
GO:0031959	mineralocorticoid receptor signaling pathway
GO:0032024	positive regulation of insulin secretion
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0032731	positive regulation of interleukin-1 beta production
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033194	response to hydroperoxide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034050	host programmed cell death induced by symbiont
GO:0035409	histone H3-Y41 phosphorylation
GO:0035556	intracellular signal transduction
GO:0035722	interleukin-12-mediated signaling pathway
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042506	tyrosine phosphorylation of Stat5 protein
GO:0042508	tyrosine phosphorylation of Stat1 protein
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043388	positive regulation of DNA binding
GO:0043392	negative regulation of DNA binding
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045597	positive regulation of cell differentiation
GO:0045822	negative regulation of heart contraction
GO:0046677	response to antibiotic
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050729	positive regulation of inflammatory response
GO:0050867	positive regulation of cell activation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060396	growth hormone receptor signaling pathway
GO:0061180	mammary gland epithelium development
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005901	caveola
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:96629

InterPro

IPR000299 FERM domain
IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020693 Tyrosine-protein kinase, non-receptor Jak2

PFAM

PF00069
PF00017
PF14633
PF07714
PF00373

PRINTS

PR00401
PR00109
PR01823
PR01825

PIRSF

PIRSF000636

SMART

SM00252
SM00220
SM00295
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References