InnateDB Protein
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IDBP-157140.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Neurog1
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Protein Name
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neurogenin 1
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Synonyms
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AKA; bHLHa6; Math4C; Neurod3; ngn1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000050484
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InnateDB Gene
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IDBG-157138 (Neurog1)
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Protein Structure
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Function |
Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. {ECO:0000269PubMed:10648228, ECO:0000269PubMed:14697366, ECO:0000269PubMed:18007592}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expression restricted to the embryonic nervous system.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107754
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
P70660
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PhosphoSite |
PhosphoSite-P70660
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18014
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UniGene |
Mm.266665
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RefSeq |
NP_035026
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MGI ID |
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MGI Symbol |
Neurog1
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OMIM |
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CCDS |
CCDS26559
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HPRD |
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IMGT |
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EMBL |
BC062148
U63841
U67776
Y09166
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GenPept |
AAB37576
AAC52856
AAH62148
CAA70365
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