InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snrpc

Summary

InnateDB Protein

IDBP-157177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snrpc

Protein Name

U1 small nuclear ribonucleoprotein C

Synonyms

Snrp1c; U1-C; U1C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063976

InnateDB Gene

IDBG-157175 (Snrpc)

Protein Structure

UniProt Annotation

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003727	single-stranded RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030619	U1 snRNA binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0000395	mRNA 5'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome

Cellular Component

GO:0000243	commitment complex
GO:0005634	nucleus
GO:0005685	U1 snRNP
GO:0015030	Cajal body
GO:0071004	U2-type prespliceosome

Protein Structure and Domains

PDB ID

MGI:109489

InterPro

IPR000690 Zinc finger, C2H2-type matrin
IPR003604 Zinc finger, U1-type
IPR013085 Zinc finger, U1-C type
IPR017340 U1 small nuclear ribonucleoprotein C

PFAM

PF06220

PRINTS

PIRSF

PIRSF037969

SMART

SM00451

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt