InnateDB Protein
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IDBP-157203.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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5033414D02Rik
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Protein Name
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RIKEN cDNA 5033414D02 gene
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Synonyms
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1110007H22Rik; 5033414D02Rik; AI852040; Plg-R(KT); Plg-RKT;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000016639
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InnateDB Gene
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IDBG-157201 (5033414D02Rik)
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Protein Structure
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Function |
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metallproteinase activation, such as of MMP2 and MMP9. {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689, ECO:0000269PubMed:21940822}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689}; Multi-pass membrane protein {ECO:0000269PubMed:19897580, ECO:0000269PubMed:21795689}. Note=Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/Plaur.
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Disease Associations |
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Tissue Specificity |
Expressed in monocytes; detected in differentiated monocytes but not in progenitor cells. Expressed in adrenal medulla and hippocampus. {ECO:0000269PubMed:21795689}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915009
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InterPro |
IPR019319
Protein of unknown function DUF2368
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PFAM |
PF10166
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D3P8
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PhosphoSite |
PhosphoSite-Q9D3P8
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TrEMBL |
D3YXU2
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UniProt Splice Variant |
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Entrez Gene |
67759
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UniGene |
Mm.391741
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RefSeq |
XP_006527368
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MGI ID |
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MGI Symbol |
Plgrkt
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OMIM |
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CCDS |
CCDS29734
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HPRD |
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IMGT |
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EMBL |
AC119228
AK017215
AK168454
AK170700
BC024953
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GenPept |
AAH24953
BAB30638
BAE40355
BAE41963
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