InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd274

Summary

InnateDB Protein

IDBP-157251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd274

Protein Name

CD274 antigen

Synonyms

A530045L16Rik; B7h1; Pdcd1l1; Pdcd1lg1; Pdl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016640

InnateDB Gene

IDBG-157249 (Cd274)

Protein Structure

UniProt Annotation

Function

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. {ECO:0000269PubMed:11015443, ECO:0000269PubMed:11238124, ECO:0000269PubMed:12719480}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the heart, thymus, skeletal muscle, and lung. Weakly expressed in the kidney, spleen, thyroid, and liver. Expressed on activated dendritic cells, B- cells and macrophages. Expressed in numerous tumor cells lines of lymphoid origin. {ECO:0000269PubMed:11015443, ECO:0000269PubMed:11224527, ECO:0000269PubMed:11238124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0031295	T cell costimulation
GO:0042130	negative regulation of T cell proliferation
GO:2001181	positive regulation of interleukin-10 secretion

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1926446

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF08205

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EP73