Version 5.4
Mus musculus Protein: Ang2
Summary
InnateDB Protein IDBP-157263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ang2
Protein Name angiogenin, ribonuclease A family, member 2
Synonyms Angrp; Raa3; Rnase5b;
Species Mus musculus
Ensembl Protein ENSMUSP00000062902
InnateDB Gene IDBG-157261 (Ang2)
Protein Structure
UniProt Annotation
Function Has ribonuclease activity (in vitro). Seems to lack angiogenic activity. {ECO:0000269PubMed:8633065}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed (at protein level) in macrophages. {ECO:0000269PubMed:16045902}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters
GO:0046872 metal ion binding
Biological Process
GO:0071333 cellular response to glucose stimulus
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005604 basement membrane
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:104984
InterPro IPR001427 Ribonuclease A
IPR023412 Ribonuclease A-domain
PFAM PF00074
PRINTS PR00794
PIRSF
SMART SM00092
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64438
PhosphoSite PhosphoSite-
TrEMBL W0UV59
UniProt Splice Variant
Entrez Gene 11731
UniGene Mm.377077
RefSeq NP_031475
MGI ID 3ZBV
MGI Symbol Ang2
OMIM
CCDS CCDS27040
HPRD
IMGT
EMBL AC163664 CH466605 HG328940 U22519
GenPept AAA91367 CDG32016 EDL20851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca