Version 5.4
Mus musculus Protein: Fbxl21
Summary
InnateDB Protein IDBP-157297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl21
Protein Name F-box and leucine-rich repeat protein 21
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000035248
InnateDB Gene IDBG-157293 (Fbxl21)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities. {ECO:0000269PubMed:18953409, ECO:0000269PubMed:23452855, ECO:0000269PubMed:23452856}.
Subcellular Localization Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus.
Disease Associations
Tissue Specificity Expressed in the hypothalamus, especially in the suprachiasmatic nucleus (SCN). Expression is driven by the core-clock. There is a pronounced diurnal and circadian expression rhythms rising rapidly at the start of the day and declining at the onset of the night. {ECO:0000269PubMed:18953409}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043153 entrainment of circadian clock by photoperiod
GO:0048511 rhythmic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:2442921
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BFZ4
PhosphoSite PhosphoSite-Q8BFZ4
TrEMBL
UniProt Splice Variant
Entrez Gene 213311
UniGene Mm.402948
RefSeq NP_848789
MGI ID
MGI Symbol Fbxl21
OMIM
CCDS CCDS26563
HPRD
IMGT
EMBL AK035290 AK079800 AK085598 BC138940 BC138941 CH466546
GenPept AAI38941 AAI38942 BAC29018 BAC37751 BAC39482 EDL41240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca