InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbr4

Summary

InnateDB Protein

IDBP-157354.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbr4

Protein Name

carbonyl reductase 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034058

InnateDB Gene

IDBG-157352 (Cbr4)

Protein Structure

UniProt Annotation

Function

The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003955	NAD(P)H dehydrogenase (quinone) activity
GO:0005515	protein binding
GO:0008753	NADPH dehydrogenase (quinone) activity
GO:0016491	oxidoreductase activity
GO:0048038	quinone binding
GO:0070402	NADPH binding

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0008152	metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:2384567

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

SM00822

TIGRFAMs

Post-translational Modifications

Modification

Cross-References