InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anks1

Summary

InnateDB Protein

IDBP-157384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anks1

Protein Name

ankyrin repeat and SAM domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085344

InnateDB Gene

IDBG-157380 (Anks1)

Protein Structure

UniProt Annotation

Function

Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. {ECO:0000269PubMed:17875921}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell projection {ECO:0000269PubMed:17875921}. Note=Cytoplasmic before and after growth factor treatment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0006929	substrate-dependent cell migration
GO:0016322	neuron remodeling
GO:0048013	ephrin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:2446180

InterPro

IPR001660 Sterile alpha motif domain
IPR002110 Ankyrin repeat
IPR006020 PTB/PI domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR021129 Sterile alpha motif, type 1

PFAM