InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brcc3

Summary

InnateDB Protein

IDBP-157389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brcc3

Protein Name

BRCA1/BRCA2-containing complex, subunit 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033544

InnateDB Gene

IDBG-157387 (Brcc3)

Protein Structure

UniProt Annotation

Function

Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0030234	enzyme regulator activity
GO:0031593	polyubiquitin binding
GO:0046872	metal ion binding

Biological Process

GO:0006302	double-strand break repair
GO:0006508	proteolysis
GO:0010165	response to X-ray
GO:0010212	response to ionizing radiation
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair
GO:0050790	regulation of catalytic activity
GO:0070536	protein K63-linked deubiquitination
GO:0070537	histone H2A K63-linked deubiquitination