Version 5.4
Mus musculus Protein: Vbp1
Summary
InnateDB Protein IDBP-157454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vbp1
Protein Name von Hippel-Lindau binding protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000033540
InnateDB Gene IDBG-157452 (Vbp1)
Protein Structure
UniProt Annotation
Function Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016272 prefoldin complex
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1333804
InterPro IPR004127 Prefoldin alpha-like
IPR009053 Prefoldin
IPR016655 Prefoldin, subunit 3
PFAM PF02996
PRINTS
PIRSF PIRSF016396
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61759
PhosphoSite PhosphoSite-P61759
TrEMBL A3KMJ8
UniProt Splice Variant
Entrez Gene 22327
UniGene Mm.8294
RefSeq NP_035822
MGI ID
MGI Symbol Vbp1
OMIM
CCDS CCDS41032
HPRD
IMGT
EMBL AK002282 AK008847 AK077923 AK151527 AK153069 AK159284 AK167064 AK169185 BC132169 BC132171 U96760
GenPept AAC23908 AAI32170 AAI32172 BAB21986 BAB25926 BAC37066 BAE30475 BAE31695 BAE34961 BAE39225 BAE40962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca