Version 5.4
Mus musculus Protein: Mex3c
Summary
InnateDB Protein IDBP-157477.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mex3c
Protein Name mex3 homolog C (C. elegans)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000089463
InnateDB Gene IDBG-157475 (Mex3c)
Protein Structure
UniProt Annotation
Function RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0003415 chondrocyte hypertrophy
GO:0008152 metabolic process
GO:0045598 regulation of fat cell differentiation
GO:0097009 energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2652843
InterPro IPR001841 Zinc finger, RING-type
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF13639
PF14634
PF00013
PF13014
PRINTS
PIRSF
SMART SM00184
SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05A36
PhosphoSite PhosphoSite-Q05A36
TrEMBL M9T283
UniProt Splice Variant
Entrez Gene 240396
UniGene Mm.400083
RefSeq NP_001034303
MGI ID
MGI Symbol Mex3c
OMIM
CCDS CCDS50318
HPRD
IMGT
EMBL AC134447 BC108422 BC125427 BR000945 KC456334 KC456335 KC456336 KC456337 KC456338 KC456339 KC456340 KC456341
GenPept AAI08423 AAI25428 AGI99519 AGI99520 AGI99521 AGI99522 AGI99523 AGI99524 AGI99525 AGI99526 FAA00737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca