InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ang4

Summary

InnateDB Protein

IDBP-157548.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ang4

Protein Name

angiogenin, ribonuclease A family, member 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073525

InnateDB Gene

IDBG-157546 (Ang4)

Protein Structure

UniProt Annotation

Function

Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro). {ECO:0000269PubMed:12548285, ECO:0000269PubMed:17279775}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000269PubMed:12548285}. Nucleus, nucleolus {ECO:0000250}. Note=Exposure to bacterial lipopolysaccharide (LPS) triggers secretion from intestinal epithelium cells.

Disease Associations

Tissue Specificity

Detected in small intestine, caecum and colon, with the highest expression in Paneth cells in the intestinal epithelium. {ECO:0000269PubMed:12548285}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004540	ribonuclease activity
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters

Biological Process

GO:0001525	angiogenesis
GO:0006401	RNA catabolic process
GO:0008284	positive regulation of cell proliferation
GO:0019731	antibacterial humoral response
GO:0042742	defense response to bacterium
GO:0090501	RNA phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic