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InnateDB Protein
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IDBP-157564.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ylpm1
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Protein Name
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YLP motif containing 1
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Synonyms
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A930013E17Rik; ZAP; Zap3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098763
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InnateDB Gene
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IDBG-157560 (Ylpm1)
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Protein Structure
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| Function |
Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation. {ECO:0000269PubMed:15511642}.
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| Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000269PubMed:10716735}. Note=Migrates to nucleolar caps upon blockage of transcription. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
15
[view]
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| Protein-Protein |
15
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
23 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0001078
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
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| Biological Process |
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GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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GO:0032204
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regulation of telomere maintenance
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| Cellular Component |
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| PDB ID |
MGI:1926195
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| InterPro |
IPR024329
Amyloidogenic glycoprotein, E2 domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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| PFAM |
PF12925
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q9R0I7
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| PhosphoSite |
PhosphoSite-Q9R0I7
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
56531
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| UniGene |
Mm.153183
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Ylpm1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AB033168
AC127582
AC155811
BC055465
CR974585
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| GenPept |
AAH55465
BAA85182
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Version 5.4