InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lipe

Summary

InnateDB Protein

IDBP-157574.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipe

Protein Name

lipase, hormone sensitive

Synonyms

4933403G17Rik; HSL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050935

InnateDB Gene

IDBG-157570 (Lipe)

Protein Structure

UniProt Annotation

Function

In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. {ECO:0000269PubMed:23291629}.

Subcellular Localization

Cell membrane {ECO:0000250}. Membrane, caveola {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Found in the high-density caveolae. Translocates to the cytoplasm from the caveolae upon insulin stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0016298	lipase activity
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0033878	hormone-sensitive lipase activity
GO:0042134	rRNA primary transcript binding

Biological Process

GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0008152	metabolic process
GO:0008203	cholesterol metabolic process
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0042758	long-chain fatty acid catabolic process
GO:0046340	diacylglycerol catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005901	caveola

Protein Structure and Domains

PDB ID

MGI:96790

InterPro

IPR010468 Hormone-sensitive lipase, N-terminal
IPR013094 Alpha/beta hydrolase fold-3
IPR019436 Steryl acetyl hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF06350
PF07859
PF10340

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54310

PhosphoSite