InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl9l

Summary

InnateDB Protein

IDBP-157597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl9l

Protein Name

B-cell CLL/lymphoma 9-like

Synonyms

B9L; BC003321; BCL9-2; DLNB11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074516

InnateDB Gene

IDBG-157593 (Bcl9l)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. {ECO:0000269PubMed:15371335}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15574752}. Note=localized also in punctate nuclear bodies as well in the cytoplasm. Colocalizes with CTNNB1.

Disease Associations

Tissue Specificity

Expressed in kidney, liver, lung, testis, brain, spleen, heart and skeletal muscle. Highly expressed in numerous colorectal tumors compared to corresponding non-cancerous tissues. {ECO:0000269PubMed:15574752}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008013	beta-catenin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0022604	regulation of cell morphogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035019	somatic stem cell maintenance
GO:0035914	skeletal muscle cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway