Version 5.4
Homo sapiens Protein: KRTAP21-2
Summary
InnateDB Protein IDBP-1576.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP21-2
Protein Name keratin associated protein 21-2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000334287
InnateDB Gene IDBG-1574 (KRTAP21-2)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005882 intermediate filament
Protein Structure and Domains
PDB ID
InterPro IPR021743 Keratin-associated protein, type6/8/16/19/20
PFAM PF11759
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3LI59
PhosphoSite PhosphoSite-Q3LI59
TrEMBL
UniProt Splice Variant
Entrez Gene 337978
UniGene Hs.553699
RefSeq NP_853648
HUGO HGNC:18946
OMIM
CCDS CCDS13605
HPRD 11215
IMGT
EMBL AB096959 AP000243
GenPept BAE46374

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca