InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpc7

Summary

InnateDB Protein

IDBP-157629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpc7

Protein Name

transient receptor potential cation channel, subfamily C, member 7

Synonyms

TRP-7; TRP7; Trrp8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022023

InnateDB Gene

IDBG-157627 (Trpc7)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus envelope {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006828	manganese ion transport
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005801	cis-Golgi network
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1349470

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005463 Transient receptor potential channel, canonical 7
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM