InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rps27a

Summary

InnateDB Protein

IDBP-157701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rps27a

Protein Name

ribosomal protein S27A

Synonyms

0610006J14Rik; Uba52; Ubb; Ubc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099908

InnateDB Gene

IDBG-157695 (Rps27a)

Protein Structure

UniProt Annotation

Function

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. {ECO:0000269PubMed:19754430}.40S Ribosomal protein S27a: Component of the 40S subunit of the ribosome. {ECO:0000269PubMed:19754430}.

Subcellular Localization

Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 167 interaction(s) predicted by orthology.