InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARP4

Summary

InnateDB Protein

IDBP-15772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARP4

Protein Name

poly (ADP-ribose) polymerase family, member 4

Synonyms

ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P; VAULT3; VPARP; VWA5C;

Species

Homo sapiens

Ensembl Protein

ENSP00000371419

InnateDB Gene

IDBG-15770 (PARP4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Also found in the nucleus, associated with mitotic spindles.

Disease Associations

Tissue Specificity

Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding

Biological Process

GO:0006281	DNA repair
GO:0006464	cellular protein modification process
GO:0006471	protein ADP-ribosylation
GO:0006810	transport
GO:0006954	inflammatory response
GO:0006974	cellular response to DNA damage stimulus
GO:0008219	cell death
GO:0042493	response to drug

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005876	spindle microtubule
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001357 BRCT domain
IPR002035 von Willebrand factor, type A
IPR004102 Poly(ADP-ribose) polymerase, regulatory domain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domain
IPR013694 VIT domain

PFAM