Version 5.4
Mus musculus Protein: Elmod3
Summary
InnateDB Protein IDBP-157736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elmod3
Protein Name ELMO/CED-12 domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000067768
InnateDB Gene IDBG-157734 (Elmod3)
Protein Structure
UniProt Annotation
Function Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity. {ECO:0000250}.
Subcellular Localization Cell projection, stereocilium {ECO:0000269PubMed:24039609}. Cell projection, kinocilium {ECO:0000269PubMed:24039609}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:24039609}. Note=Also present in the cuticular plate of auditory hair cells. In the organ of Corti, in inner hair cells, expressed along the length of the stereocilia, but excluded from the very tip. Colocalizes with F-actin cytoskeleton.
Disease Associations
Tissue Specificity Both isoform 1 and isoform 2 are widely expressed. {ECO:0000269PubMed:24039609}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006909 phagocytosis
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0032420 stereocilium
GO:0060091 kinocilium
Protein Structure and Domains
PDB ID MGI:2445168
InterPro IPR006816 Engulfment/cell motility, ELMO
PFAM PF04727
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YP6
PhosphoSite PhosphoSite-Q91YP6
TrEMBL D3Z5B5
UniProt Splice Variant
Entrez Gene 232089
UniGene Mm.167232
RefSeq NP_001240621
MGI ID
MGI Symbol Elmod3
OMIM
CCDS CCDS20243
HPRD
IMGT
EMBL AC125039 AC154002 AK049155 AK084010 AK164974 BC016193
GenPept AAH16193 BAC33574 BAC39096 BAE37985

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca