Version 5.4
| Mus musculus Protein: Ceacam2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-157773.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ceacam2 | ||||||||
| Protein Name | carcinoembryonic antigen-related cell adhesion molecule 2 | ||||||||
| Synonyms | AI267129; Bgp2; Ceacam2-L; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000064255 | ||||||||
| InnateDB Gene | IDBG-157771 (Ceacam2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the virus.Isoform 2 may be an adhesion molecule contributing to cell to cell adhesion between elongating spermatids and Sertoli cells within the seminiferous epithelium. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:23070997}; Single-pass type I membrane protein {ECO:0000269PubMed:23070997}. Note=Localizes to sites on the plasma membrane of elongating spermatids where Sertoli cells make contact. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Isoform 2 is detected in elongating spermatids within the seminiferous epithelium (at protein level). Expressed in kidney, colon, uterus, gut mononuclear cells, crypt epithelia of intestinal tissues, and to a lesser extent, in spleen. Expressed in brain including VMH, globus pallidus, ventral pallidum, striatum, olfactory bulb and hippocampus. Also detected in rectal carcinoma cell line CMT93. Isoform 2 and isoform 3 are expressed in testis. Isoform 2 is detected in seminiferous tubule, not detected in epididymal spermatozoa. Also not observed on spermatogonia, spermatocytes, round spermatids or somatic Sertoli cells. During stages I-VII of spermatogenesis, detected on the elongating spermatids. At spermiation (stage VIII) and subsequent stages IX-XII, levels are drastically reduced or absent in the seminiferous tubules. Sometimes weakly detected in the apical region of stage-VIII seminiferous epithelium. Isoform 2 level is very low in stomach, kidney, intestine, liver and spleen. {ECO:0000269PubMed:10491101, ECO:0000269PubMed:11284729, ECO:0000269PubMed:20381490, ECO:0000269PubMed:23070997, ECO:0000269PubMed:8207827}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1347246 | ||||||||
| InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin |
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| PFAM |
PF07679
PF07686 PF00047 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00408
SM00409 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q925P2 | ||||||||
| PhosphoSite | PhosphoSite-Q925P2 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 26367 | ||||||||
| UniGene | Mm.439731 | ||||||||
| RefSeq | NP_001106840 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Ceacam2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS52152 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB500065 AB731450 AC162443 AF101164 AF287912 BC024320 X76085 | ||||||||
| GenPept | AAC99458 AAH24320 AAK52602 BAI49177 BAM29120 CAA53699 | ||||||||