Version 5.4
| Mus musculus Protein: Retsat | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-157806.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Retsat | ||||||||
| Protein Name | retinol saturase (all trans retinol 13,14 reductase) | ||||||||
| Synonyms | 0610039N19Rik; C80029; MMT-7; Ppsig; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000068568 | ||||||||
| InnateDB Gene | IDBG-157804 (Retsat) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A. {ECO:0000269PubMed:15358783}. | ||||||||
| Subcellular Localization | Endoplasmic reticulum membrane {ECO:0000269PubMed:15358783}; Peripheral membrane protein {ECO:0000269PubMed:15358783}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Predominantly expressed in the liver and kidney. Also expressed in intestine, white fat and brown fat. Weakly expressed in heart, skeletal muscle and testis and barely detected in the lung, brain and spleen. {ECO:0000269PubMed:15358783, ECO:0000269PubMed:18289917}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1914692 | ||||||||
| InterPro |
IPR002937
Amine oxidase IPR003953 FAD binding domain IPR006076 FAD dependent oxidoreductase |
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| PFAM |
PF01593
PF00890 PF01266 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q64FW2 | ||||||||
| PhosphoSite | PhosphoSite-Q64FW2 | ||||||||
| TrEMBL | A4FUU4 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 67442 | ||||||||
| UniGene | Mm.442909 | ||||||||
| RefSeq | NP_080435 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Retsat | ||||||||
| OMIM | |||||||||
| CCDS | CCDS20244 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC125039 AF466400 AK002851 AK144115 AY704159 BC011203 BC117750 BC117751 CH466523 EF620363 EF620364 EF620365 EF620366 | ||||||||
| GenPept | AAH11203 AAI17751 AAI17752 AAL73986 AAU25836 ABS17600 ABS17601 ABS17602 ABS17603 BAB22406 BAE25708 EDK98989 | ||||||||