InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlst

Summary

InnateDB Protein

IDBP-157811.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlst

Protein Name

dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)

Synonyms

1600017E01Rik; 4632413C10Rik; 4930529O08Rik; DLTS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000060346

InnateDB Gene

IDBG-157807 (Dlst)

Protein Structure

UniProt Annotation

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004149	dihydrolipoyllysine-residue succinyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process
GO:0033512	L-lysine catabolic process to acetyl-CoA via saccharopine

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0045252	oxoglutarate dehydrogenase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1926170

InterPro

IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR006255 Dihydrolipoamide succinyltransferase
IPR011053 Single hybrid motif

PFAM

PF00364
PF00198

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D2G2

PhosphoSite