Version 5.4
Mus musculus Protein: Arhgef40
Summary
InnateDB Protein IDBP-157897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef40
Protein Name Rho guanine nucleotide exchange factor (GEF) 40
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000091331
InnateDB Gene IDBG-157895 (Arhgef40)
Protein Structure
UniProt Annotation
Function May act as a guanine nucleotide exchange factor (GEF). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Concentrated in the perinuclear region. {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed but enriched in brain. In brain, it is expressed at higher level in olfactory bulb and cerebellum and peaks perinatally (from E16 to P0.5). {ECO:0000269PubMed:16143467}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0008150 biological_process
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2685515
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UPH7
PhosphoSite PhosphoSite-Q3UPH7
TrEMBL S4R2R3
UniProt Splice Variant
Entrez Gene 268739
UniGene Mm.9239
RefSeq NP_937892
MGI ID
MGI Symbol Arhgef40
OMIM
CCDS CCDS49488
HPRD
IMGT
EMBL AC157572 AK131136 AK134295 AK143527 AK147761 AK155659 BC058405 BC059018
GenPept AAH58405 AAH59018 BAD21386 BAE22088 BAE25418 BAE28120 BAE33372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca