InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ska1

Summary

InnateDB Protein

IDBP-157913.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ska1

Protein Name

spindle and kinetochore associated complex subunit 1

Synonyms

2810433K01Rik; AV117428;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049156

InnateDB Gene

IDBG-157911 (Ska1)

Protein Structure

UniProt Annotation

Function

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid-anaphase and then vanishes in telophase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding

Biological Process

GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0051301	cell division

Cellular Component

GO:0000940	condensed chromosome outer kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005876	spindle microtubule
GO:0015630	microtubule cytoskeleton