InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grpel1

Summary

InnateDB Protein

IDBP-158105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grpel1

Protein Name

GrpE-like 1, mitochondrial

Synonyms

AA408748; mt-GrpE#1; mt-Grpel1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031099

InnateDB Gene

IDBG-158103 (Grpel1)

Protein Structure

UniProt Annotation

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000774	adenyl-nucleotide exchange factor activity
GO:0042803	protein homodimerization activity
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding