InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgf

Summary

InnateDB Protein

IDBP-158124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgf

Protein Name

placental growth factor

Synonyms

AI854365; PIGF; Plgf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004913

InnateDB Gene

IDBG-158122 (Pgf)

Protein Structure

UniProt Annotation

Function

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001666	response to hypoxia
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0030154	cell differentiation
GO:0031100	organ regeneration
GO:0032870	cellular response to hormone stimulus
GO:0042493	response to drug
GO:0045766	positive regulation of angiogenesis
GO:0051781	positive regulation of cell division
GO:0060688	regulation of morphogenesis of a branching structure