InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AMH

Summary

InnateDB Protein

IDBP-15820.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AMH

Protein Name

anti-Mullerian hormone

Synonyms

MIF; MIS;

Species

Homo sapiens

Ensembl Protein

ENSP00000221496

InnateDB Gene

IDBG-15818 (AMH)

Protein Structure

UniProt Annotation

Function

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

Subcellular Localization

Secreted.

Disease Associations

Persistent Muellerian duct syndrome 1 (PMDS1) [MIM:261550]: A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. {ECO:0000269PubMed:8162013, ECO:0000269PubMed:8872466}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005160	transforming growth factor beta receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001541	ovarian follicle development
GO:0001546	preantral ovarian follicle growth
GO:0001655	urogenital system development
GO:0001880	Mullerian duct regression
GO:0007267	cell-cell signaling
GO:0007506	gonadal mesoderm development
GO:0007530	sex determination
GO:0007548	sex differentiation
GO:0007568	aging
GO:0008406	gonad development
GO:0010628	positive regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0042493	response to drug
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001839 Transforming growth factor-beta, C-terminal
IPR006799 Anti-Mullerian hormone, N-terminal
IPR021203 Muellerian-inhibiting factor
IPR029034 Cystine-knot cytokine

PFAM

PF00019
PF04709

PRINTS

PIRSF

PIRSF037270

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt