InnateDB Protein
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IDBP-158342.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rmi1
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Protein Name
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RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
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Synonyms
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4932432N11Rik; C79893;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000041035
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InnateDB Gene
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IDBG-158340 (Rmi1)
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Protein Structure
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Function |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Forms foci in response to DNA damage. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921636
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InterPro |
IPR013894
Domain of unknown function DUF1767
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PFAM |
PF08585
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9D4G9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74386
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UniGene |
Mm.85289
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RefSeq |
NP_083180
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MGI ID |
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MGI Symbol |
Rmi1
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OMIM |
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CCDS |
CCDS26571
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HPRD |
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IMGT |
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EMBL |
AK016542
AK032229
AK079457
BC037694
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GenPept |
AAH37694
BAB30292
BAC27772
BAC37651
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