InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nek9

Summary

InnateDB Protein

IDBP-158375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nek9

Protein Name

NIMA (never in mitosis gene a)-related expressed kinase 9

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049056

InnateDB Gene

IDBG-158373 (Nek9)

Protein Structure

UniProt Annotation

Function

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:2387995

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00415
PF00069
PF07714

PRINTS

PR00633
PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt