InnateDB Protein
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IDBP-158422.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eaf2
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Protein Name
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ELL associated factor 2
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Synonyms
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AW048865; Festa; FESTA-L; FESTA-S; Traits; U19;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000075331
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InnateDB Gene
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IDBG-158420 (Eaf2)
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Protein Structure
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Function |
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity. {ECO:0000250, ECO:0000269PubMed:12761297}.
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Subcellular Localization |
Nucleus speckle {ECO:0000250}. Note=Colocalizes with ELL to nuclear speckles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in ovary, uterus, mammary glands, brain, spleen, liver, lung, thymus, kidney, skeletal muscle, skin and testis. Isoform 2 is expressed in kidney. {ECO:0000269PubMed:12761297, ECO:0000269PubMed:14517999}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0030308
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negative regulation of cell growth
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GO:0045893
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positive regulation of transcription, DNA-templated
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GO:0060770
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negative regulation of epithelial cell proliferation involved in prostate gland development
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GO:0097193
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intrinsic apoptotic signaling pathway
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Cellular Component |
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PDB ID |
MGI:2146616
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91ZD6
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PhosphoSite |
PhosphoSite-Q91ZD6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
106389
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UniGene |
Mm.432078
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RefSeq |
NP_598872
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MGI ID |
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MGI Symbol |
Eaf2
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OMIM |
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CCDS |
CCDS37335
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HPRD |
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IMGT |
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EMBL |
AB081298
AY034479
AY049021
BC004721
BC056626
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GenPept |
AAH04721
AAH56626
AAK59701
AAL12224
BAC77525
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