InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lamc3

Summary

InnateDB Protein

IDBP-158442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamc3

Protein Name

laminin gamma 3

Synonyms

AI562206; AW240805;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028187

InnateDB Gene

IDBG-158440 (Lamc3)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Disease Associations

Tissue Specificity

Strongly expressed in capillaries and arterioles of kidney as well as in interstitial Leydig cells of testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0007155	cell adhesion
GO:0007601	visual perception
GO:0014002	astrocyte development
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane

Protein Structure and Domains

PDB ID

MGI:1344394

InterPro

IPR000034 Laminin B type IV
IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR008979 Galactose-binding domain-like
IPR018031 Laminin B, subgroup

PFAM

PF00052
PF00008
PF00053
PF00055

PRINTS

PIRSF

SMART

SM00181
SM00180
SM00136
SM00281

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9R0B6